Vicky Donor story begins with Dr Chaddha (annu kapoor) who runs a fertility clinic in Delhi and despite his best efforts he is unable to get success. He realizes that a healthy sperm donor is the only solution. On the other hand, there is Vicky (ayushman) who lives in a middle class locality in Delhi. His mother Dolly (dolly) is a widow who runs a beauty parlor. The story takes a turn when a tiff happens between Vicky and Dr Chaddha and realizes that Vicky is the one who can become a donor. Meanwhile, Vicky falls in love with Ashima (yami) a bank employee. What happens after that forms the rest of the story.